HORDB

ID: hor005269
Uniprot ID: P68007
Protein name: Neuropeptide Y
Gene name: NPY
Organism: Alligator mississippiensis (American alligator)
Family: NPY family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Alligator (genus), Alligatorinae (subfamily), Alligatoridae (family), Crocodylia (order), Archosauria, Archelosauria, Sauria, Sauropsida, Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: GO:0005576 extracellular region

Function: NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.
Mechanism: NA
Cross BBB: NA
Target: NPY2R
Target Unid: A0A151PB76
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: ~ 20 (20-28) minutes; /1200 seconds ( PubMed ID: 3601235 )

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-P68007-F1.pdb

hor005269_AF2.pdb

hor005269_ESM.pdb

Mass:	489718	Formula:	C189H284N54O58S
Absent amino acids:	CFVW	Common amino acids:	Y
pI:	7.52	Basic residues:	6
Polar residues:	11	Hydrophobic residues:	8
Hydrophobicity:	-119.44	Boman Index:	-10835
Half-Life:	2.8 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	2 min	Aliphatic Index	54.44
Instability Index:	6373.89	Extinction Coefficient cystines:	7450
Absorbance 280nm:	212.86

PubMed ID: 8101369
Title: Neuroendocrine peptides (NPY, GRP, VIP, somatostatin) from the brain and stomach of the alligator.
PubMed ID: 8351403
Title: Primary structure of neuropeptide Y from brains of the American alligator (Alligator mississippiensis).
PubMed ID: 3601235
Title: